Key result
Concomitant use of commonly used antibiotics is associated with an increased risk of bleeding, such as spontaneous abdominal hemorrhage, among patients receiving long-term warfarin therapy.
Case Report
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Highlights the risk of severe spontaneous bleeding, such as abdominal wall and intra-pelvic hematomas, when short courses of antibiotics are prescribed to patients on long-term warfarin therapy.
Warfarin is the most commonly used anticoagulant in clinical practice. Despite its advantages it has serious side effects mainly bleeding due to narrow therapeutic range and several drug and food interactions. Spontaneous abdominal haemorrhage is one of the rare bleeding manifestations of it. Concomitant use of commonly used antibiotic are associated with an increased risk of bleeding among patients receiving warfarin.
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Ruwana et al. (2016) conducted a case report in Abdominal wall and intra-pelvic hematoma. Short course of antibiotics during long-term warfarin therapy was evaluated. Concomitant use of commonly used antibiotics is associated with an increased risk of bleeding, such as spontaneous abdominal hemorrhage, among patients receiving long-term warfarin therapy.
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