Key result
A 62-year-old woman with primary malignant fibrous histiocytoma of the pleura presented with pleural effusion and thickening, and died of cardiac tamponade 3 months after admission.
Case Report (n=1)
Primary pleural malignant fibrous histiocytoma is an extremely rare and highly aggressive tumor that can lead to rapid death from complications such as cardiac tamponade.
A case of malignant fibrous histiocytoma (MFH) of the pleura is presented. A 62 year old woman was admitted because of cough and general malaise. Chest X-ray film showed left pleural effusion and thickening. Though she received antituberculous agents, she died about 3 months after admission. Autopsy revealed the left pleural thickening which was diagnosed as MFH. The tumor had metastasized to many organs; lung, liver, stomach, duodenum, kidneys, adrenal glands, thyroid, heart, lymphnodes. Histologically, the tumor consisted mainly of fibroblast-like cells, histiocyte-like cells and bizarre giant cells, which were arranged in a storiform pattern. The mesothelioma was neglected because PAS and Alcian Blue staining were negative and immunohisto-chemical technique for α1-antichymotrypsin was positive.
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Nishimura et al. (1985) conducted a case report in Malignant fibrous histiocytoma of the pleura (n=1). Malignant fibrous histiocytoma was evaluated on Mortality. A 62-year-old woman with primary malignant fibrous histiocytoma of the pleura presented with pleural effusion and thickening, and died of cardiac tamponade 3 months after admission.
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