Key result
Low-dose γ radiation provided significant prophylaxis against doxorubicin-induced nephropathy in rats, an effect augmented by natural antioxidants such as l-carnitine, curcumin, and garlic.
Why the study?
Does low-dose γ radiation alone or with natural antioxidants protect against doxorubicin-induced nephropathy in rats?
Does low-dose γ radiation alone or with natural antioxidants protect against doxorubicin-induced nephropathy in rats?
Low-dose γ radiation, particularly when combined with natural antioxidants, may provide prophylaxis against doxorubicin-induced nephropathy in a rat model.
Hypothesis-generating for doxorubicin nephropathy prophylaxis; requires human trials before any clinical consideration.
The protective potentials of a single exposure to 0.3 Gy of γ radiation alone or with previous treatment with certain natural products with antioxidants activity, namely curcumin (50 mg/kg, i.p.), green tea (300 mg/kg, p.o.), garlic (100 mg/kg, p.o.) or l-carnitine (40 mg/kg, i.p.) against doxorubicin (DOX)-induced nephropathy in rats were studied. Natural products were administered daily for 14 successive days followed by single i.p. injection of DOX (5 mg/kg). Rats were subjected to whole body γ radiation, 1 day before DOX administration. Serum levels of creatinine, urea, uric acid, low density lipoprotein (LDL-C), high density lipoprotein (HDL-C) cholesterols, total proteins and albumin as well as renal concentrations of reduced glutathione (GSH), thiobarbituric acid reactive substances (TBARS), nitric oxide (NO) and calcium (Ca) were determined. Irradiation provided significant protections against DOX-induced changes in all measured parameters, except renal Ca content. All the test natural products significantly improved radiation-induced protection against renal lipid peroxidation. l-Carnitine markedly augmented the protection toward changes in renal GSH, NO and Ca concentrations. Curcumin increased the protection toward changes in serum albumin and renal GSH and NO concentrations, while garlic increased the protection toward changes in serum LDL-C level. It could be concluded that low-dose γ radiation could provide prophylaxis against DOX-induced nephropathy which might be augmented by the use of certain natural antioxidants.
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Radwan et al. (2012) studied Doxorubicin-induced nephropathy. Low-dose γ radiation alone or with natural products vs. Doxorubicin alone was evaluated on Serum and renal markers of nephropathy and oxidative stress. Low-dose γ radiation provided significant prophylaxis against doxorubicin-induced nephropathy in rats, an effect augmented by natural antioxidants such as l-carnitine, curcumin, and garlic.
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