Numerous recently published data on the methods for modification of protoporphyrin IX and its derivatives have been summarized and analyzed. Special attention has been given to those transformations which are important from the practical viewpoint for the preparation of compounds possessing valuable medical, biological, and physical properties, as well as to specific transformations inherent to the tetrapyrrole macroring.
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V. Yu. Pavlov (2007) studied this question.
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