Key result
Carotid intima media thickness was significantly higher in peritoneal dialysis patients than healthy controls (0.83 vs. 0.77 mm; p<0.01) and independently correlated with OS markers and ADMA.
Why the study?
Are oxidative stress markers and ADMA associated with increased carotid intima media thickness in peritoneal dialysis patients?
Case-Control (n=60)
Are oxidative stress markers and ADMA associated with increased carotid intima media thickness in peritoneal dialysis patients?
Oxidative stress markers and ADMA are independently associated with increased carotid intima media thickness in peritoneal dialysis patients, suggesting a role in accelerated atherosclerosis.
Answers are grounded in this paper and cite their sources.
Supports oxidative stress and ADMA as contributors to subclinical atherosclerosis in peritoneal dialysis; leaves open whether modulation alters progression.
BACKGROUND: Oxidative stress (OS) and asymmetric dimethylarginine (ADMA) are accepted as nonclassical cardiovascular risk factors in end-stage renal disease patients. To clarify the role of these factors in the atherosclerotic process, we investigated if OS and ADMA are associated with common carotid artery intima media thickness (CIMT) in peritoneal dialysis (PD) patients. METHODS: Thirty PD patients without known atherosclerotic disease and classical cardiovascular risk factors as well as age- and gender-matched 30 healthy individuals were included. We measured serum thiobarbituric acid-reactive substances (TBARS), malondialdehyde (MDA), advanced glycation end product (AGE), pentosidine, advanced oxidation protein products (AOPP), ADMA and CIMT in each subjects. RESULTS: TBARS, MDA, AOPP, AGE, pentosidine and ADMA levels were significantly higher in PD patients than in controls (p < 0.001). CIMT in patients was higher than in the control group (0.83 +/- 0.09 vs. 0.77 +/- 0.06 mm; p < 0.01). CIMT was independently correlated with TBARS (beta = 0.33, p < 0.01), MDA (beta = 0.27, p < 0.01), AOPP (beta = 0.22, p < 0.02), AGE (beta = 0.45, p < 0.01), pentosidine (beta = 0.56, p < 0.01) and ADMA (beta = 0.54, p < 0.01). CONCLUSIONS: OS markers and serum ADMA levels independently predict the CIMT level in PD patients.
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Koçak et al. (2007) conducted a case-control in Peritoneal dialysis (n=60). Peritoneal dialysis vs. Healthy individuals was evaluated on Carotid intima media thickness (CIMT) (p=<0.01). Carotid intima media thickness was significantly higher in peritoneal dialysis patients than healthy controls (0.83 vs. 0.77 mm; p<0.01) and independently correlated with OS markers and ADMA.
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