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Typically, all cells of a chronic lymphocytic leukemia (CLL) clone share a unique structure of B-cell receptor, as they are the progeny of a single B-lymphocyte. This is due to the mechanism of allelic exclusion that ensures the expression of only one allele in immunoglobulin (IG) heavy chain locus (IGH) and one either in IG light chain Kappa or Lambda loci (IGK, IGL) that were productively rearranged. However, current evidence suggests that up to a quarter of CLL patients express not only one but multiple clonal productive IGH rearrangements. 1 , 2
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Brázdilová et al. (2017) studied this question.
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