Key result
The von Willebrand factor type A (VWA) domain of CLCA1 is necessary and sufficient to increase TMEM16A protein levels at the cell surface and activate TMEM16A-like currents in HEK293T cells.
Population
HEK293T cells
Design
Preclinical
Authors
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May inform TMEM16A-targeted cystic fibrosis therapies; leaves open translation from cell models to in vivo or clinical use.
The VWA domain of CLCA1 selectively activates TMEM16A chloride channels by stabilizing them at the cell surface, highlighting a potential therapeutic mechanism for cystic fibrosis.
Sala‐Rabanal et al. (2017) studied this question. CLCA1 VWA domain was evaluated on TMEM16A channel activity and cell surface protein levels. The von Willebrand factor type A (VWA) domain of CLCA1 is necessary and sufficient to increase TMEM16A protein levels at the cell surface and activate TMEM16A-like currents in HEK293T cells.
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