Key result
Intravenous magnesium sulphate significantly prolonged the mean time to rescue analgesia to 444 minutes compared to 287 minutes with placebo in patients undergoing lower limb orthopaedic surgeries.
Why the study?
The study was conducted to observe total analgesic requirement, time to rescue analgesia, and complication rates in the first 24 hours postoperatively with magnesium sulphate versus control.
Does IV magnesium sulphate reduce postoperative analgesic requirement in patients undergoing lower limb orthopaedic surgeries under spinal anaesthesia?
RCT (n=50)
Single-blind
Simple random sampling using a closed envelope method
Does IV magnesium sulphate reduce postoperative analgesic requirement in patients undergoing lower limb orthopaedic surgeries under spinal anaesthesia?
Absolute Event Rate: 444% vs 287%
p-value: p=0.001
Intravenous magnesium sulphate (50 mg/kg) safely prolongs the time to rescue analgesia and reduces total analgesic requirements in the first 24 hours after lower limb orthopaedic surgery under spinal anaesthesia.
May reduce early postoperative analgesic needs after spinal anesthesia; hypothesis-generating and requires confirmation in larger trials.
Objective: To observe the total analgesic requirement in the first 24 hrs of the postoperative period, if there is any prolongation of the time to rescue analgesia and incidence of complications in patients given Magnesium sulphate and the control group.Methods: The study comprised 50 patients undergoing lower limb orthopaedic surgery who were ASAGrade I & II and were between the age of 20 and 65.After receiving spinal anaesthesia, 25 of these patients (Group A) got Magnesium Sulphate at a dose of 50 mg/kg in 100 ml bottles of normal saline, while the other 25 patients (Group B) received only NS (Group B).It was recorded when the first dose of analgesia was needed.Patients were watched for signs of sedation, hypotension, shivering, nausea, vomiting and pruritus.The total amount of analgesics needed in the first 24 hours following the operation was noted.Results: In Group A and Group B, the mean ± SD of the time to rescue analgesia was 444± 130 minutes and 287± 55 minutes, respectively.The total analgesic requirement of Group A was significantly less as compared to Group B in the first 24 hours of the surgery.Incidence of complications were not significantly higher in the study group.Conclusion: We come to the conclusion that patients receiving spinal anaesthesia for lower limb orthopaedic procedures can safely receive IV magnesium sulphate in a bolus dose of 50 mg/kg to reduce initial postoperative pain with a minimal incidence of complications.
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Jinal Subhash Tanna Janam (2023) conducted an RCT in Postoperative pain in lower limb orthopaedic surgeries (n=50). Magnesium Sulphate vs. 100 ml normal saline IV was evaluated on Time to rescue analgesia (minutes) (p=0.001). Intravenous magnesium sulphate significantly prolonged the mean time to rescue analgesia to 444 minutes compared to 287 minutes with placebo in patients undergoing lower limb orthopaedic surgeries.
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