Key result
Perioperative use of alpha-2 adrenergic agonists counteracts sympathetic stimulation, enhances conduction block with local anesthetics, and is beneficial for postoperative pain in vulnerable patients.
Alpha-2 adrenergic agonists enhance the quality and duration of conduction block with local anesthetics and are beneficial for postoperative pain management.
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May support adjunctive use for perioperative analgesia in vulnerable patients; hypothesis-generating and requires prospective RCTs before practice change.
The sympatholytic effect of α2-agonists counteracts the sympathetic stimulation seen with the newer volatile anesthetic agents. Alpha-2 agonists enhance both the quality and the duration of conduction block with local anesthetics and its use for postoperative pain has been established firmly. The beneficial effects of α2-agonists in the immediate postoperative period appear to be particularly useful for vulnerable patients.
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Kamibayashi et al. (1996) conducted a review in Perioperative care and postoperative pain. Alpha-2 adrenergic agonists was evaluated. Perioperative use of alpha-2 adrenergic agonists counteracts sympathetic stimulation, enhances conduction block with local anesthetics, and is beneficial for postoperative pain in vulnerable patients.
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