Key result
Amifostine at /kg or dexamethasone reduced oxidative stress markers and improved electrocardiographic and histopathological findings in rats with trauma-induced cardiac contusion.
Why the study?
To examine whether two different doses of amifostine and dexamethasone have ameliorative effects on pathologic changes associated with trauma-induced cardiac contusion in rats.
Does amifostine or dexamethasone improve histopathological, biochemical, and electrocardiographic outcomes in a rat model of blunt chest trauma-induced cardiac contusion?
Does amifostine or dexamethasone improve histopathological, biochemical, and electrocardiographic outcomes in a rat model of blunt chest trauma-induced cardiac contusion?
In a rat model of blunt cardiac trauma, amifostine (400 mg/kg) or dexamethasone (10 mg/kg) administered early after injury ameliorated myocardial damage, oxidative stress, and ECG abnormalities.
Answers are grounded in this paper and cite their sources.
Ameliorative effects of amifostine and dexamethasone in rat cardiac contusion remain hypothesis-generating; human trials needed before clinical consideration.
BACKGROUND: This study aimed to examine whether two different doses of dexamethasone (DXM), which is a corticosteroid, and amifostine (AMI), which reduces cumulative tissue toxicity induced by cisplatin in advanced-stage cancer patients, have ameliorative effects on pathologic changes associated with cardiac contusion (CC) induced in rats. METHODS: Forty-two Wistar albino rats were equally divided into six groups (n=7): C, CC, CC+AMI 400, CC+AMI 200, CC+AMI+DXM, and CC+DXM. Tomography images and electrocardiographic analyzes were performed, mean arterial pressure was measured from the carotid artery, and blood and tissue samples were obtained for histopathological and biochemical analyses after trauma-induced CC. RESULTS: While the total oxidant status and disulfide parameters in the cardiac tissue and serum were significantly higher (p<0.05), the total antioxidant status, total thiol, and native thiol parameters were significantly lower (p<0.01) in rats with trauma-induced CC. The most frequently observed finding in the electrocardiography analyze was ST elevation. CONCLUSION: According to evaluation based on histological, biochemical, and electrocardiographic examinations, we believe that only 400 mg/kg dose of AMI or DXM can be effective in the treatment of myocardial contusion in rats. Evaluation based on histological findings.
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Ahmet Acıpayam (2023) studied Blunt chest trauma-induced cardiac contusion (n=42). Amifostine vs. Untreated cardiac contusion was evaluated on Total oxidant status and disulfide parameters (p=<0.01). Amifostine at /kg or dexamethasone reduced oxidative stress markers and improved electrocardiographic and histopathological findings in rats with trauma-induced cardiac contusion.
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