Addicted to caffeine? The caffeine molecule is strongly held in a 1:1 complex with the first artificial C3-symmetrical caffeine receptor 1, which is based on functionalized triphenylene ketals. Molecular recognition by this receptor involves hydrogen bonds and π-donor–π-acceptor stacking, as shown by 1H NMR spectroscopic experiments and a crystal structure analysis.
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Waldvogel et al. (2000) studied this question.
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