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The cation-𝜋 interaction is a non-covalent interaction with significant role in healthcare such as biochemical systems or molecular neurobiology. The cation-𝜋 interaction is regarded as a strong non-covalent interaction in aqueous solutions essential for ligand–protein interfaces and delivery of chemical drugs. Limited knowledge is available regarding the manufacturing of synthetic functional materials (i.e. self-healing hydrogels) by availing the cation-𝜋 interaction. This mini-review aims to provide a brief summary on the importance of the cation-𝜋 interaction for protein stability and describes the impact on the secondary structure of proteins. Furthermore, it examines the cation-𝜋 interaction in medical applications and its impact in a receptor ligand that applies to neurobiology.
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Bergsma et al. (2022) studied this question.
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