Key result
In patients with von Willebrand disease, the bleeding severity score was the most significant determinant of bleeding requiring therapy (HR 5.5; 95% CI 2.8-10.8).
Population
814 Italian patients with von Willebrand disease followed prospectively for one year.
Design
Cohort
Follow-up
1 year
Authors
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May support bleeding severity scoring for risk stratification in von Willebrand disease; leaves open prospective validation before guiding therapy.
Cohort (n=814)
Yes
Hazard Ratio: 5.5 (95% CI 2.8–10.8)
In patients with von Willebrand disease, a bleeding severity score >10 is a strong independent predictor of future bleeding episodes requiring treatment.
Federici et al. (2007) conducted a cohort in von Willebrand disease (n=814). Bleeding severity score (BSS) was evaluated on Bleeding requiring therapy with DDAVP and/or VWF concentrates (HR 5.5, 95% CI 2.8-10.8). In patients with von Willebrand disease, the bleeding severity score was the most significant determinant of bleeding requiring therapy (HR 5.5; 95% CI 2.8-10.8).
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