Key result
Elevated baseline levels of inflammatory cytokines independently predicted the occurrence of post-PCI coronary slow flow in patients with NSTE-ACS, including hs-CRP, sIL-2R, and TNF-α.
Why the study?
Coronary slow flow after PCI implies poor outcomes, but its determinants in patients with NSTE-ACS remain controversial.
Are elevated levels of inflammatory cytokines associated with post-PCI coronary slow flow in patients with NSTE-ACS?
Case-Control (n=528)
Yes
Are elevated levels of inflammatory cytokines associated with post-PCI coronary slow flow in patients with NSTE-ACS?
Answers are grounded in this paper and cite their sources.
Elevated circulating levels of inflammatory cytokines, specifically hs-CRP, sIL-2R, and TNF-α, are independent predictors of post-PCI coronary slow flow in patients with NSTE-ACS.
To evaluate the association between circulating levels of inflammatory cytokines and the occurrence of post-percutaneous coronary intervention (PCI) coronary slow flow (CSF) in patients with non-ST segment elevation acute coronary syndrome (NSTE-ACS). CSF after PCI commonly occurs and implies poor outcomes, while the determinants of post-PCI CSF in patients with NSTE-ACS remain controversial. In this multicenter case control study, 176 patients diagnosed with NSTE-ACS and with post-PCI CSF occurred composed of CSF group, while 352 matched NSTE-ACS patients composed control group. Corrected thrombolysis in myocardial infarction frame count (cTFC), circulating levels of inflammatory cytokines and PCI related parameters were analyzed using Logistic regression models. Among 528 patients with median age of 67 (59-76) and male proportion of 65.5%, 176 (35.0%) patients had occurrence of post-PCI CSF defined as cTFC ≥ 24. Patients with CSF presented more intense inflammatory activity revealed by higher levels of white blood cell, high-sensitivity C-reactive protein (hs-CRP), interleukin-1ß (IL-1ß), soluble IL-2 receptor (sIL-2R), IL-6, IL-8, IL-10 and tumor necrosis factor-α (TNF-α), while PCI related parameters were comparable. Correlation analysis showed cTFC was positively correlated with those inflammatory cytokines. Logistic regression model indicates that hs-CRP (odds ratio (OR) = 3.038, 95% confidence interval (CI) 1.545-5.975), sIL-2R (OR = 2.103, 95% CI 1.959-4.026) and TNF-α (OR = 3.708, 95% CI 1.426-9.641) were valuable predictors for CSF occurrence. Elevated circulating levels of inflammatory cytokine including hs-CRP, sIL-2R and TNF-α rather than PCI related parameters could predict post-PCI CSF in patients with NSTE-ACS.
No takes yet. Share an insight, caveat, or question.
Wang et al. (2022) conducted a case-control in Non-ST segment elevation acute coronary syndrome (NSTE-ACS) (n=528). Elevated hs-CRP vs. hs-CRP below cut-off value was evaluated on Occurrence of post-PCI coronary slow flow (CSF) (OR 3.038, 95% CI 1.545-5.975, p=0.001). Elevated baseline levels of inflammatory cytokines independently predicted the occurrence of post-PCI coronary slow flow in patients with NSTE-ACS, including hs-CRP, sIL-2R, and TNF-α.
Synapse has enriched 10 related papers. Consider them for comparative context: