Key result
Serum interleukin-6 levels were significantly higher in heart failure patients (median 14.3 pg/mL) compared to age- and sex-matched healthy controls (median 0 pg/mL).
Why the study?
Are serum interleukin-6 levels elevated in heart failure patients compared to healthy controls?
Case-Control (n=44)
Yes
Are serum interleukin-6 levels elevated in heart failure patients compared to healthy controls?
Absolute Event Rate: 14.3% vs 0%
p-value: p=<0.0005
Serum interleukin-6 levels are significantly elevated in heart failure patients, supporting its role as a pro-inflammatory marker in the disease.
Should not yet change heart failure management; hypothesis-generating for IL-6-targeted therapies in prospective trials.
Background: A growing body of evidence suggests that inflammation plays the key role in different cardiovascular diseases. But very study has been done so far in relation to serum interleukin-6 in heart failure patients. The aim of the study was to measure serum interleukin-6 in heart failure patients.Methods: Total 22 heart failure patients and 22 age and sex matched controls were included in this study from August 2015 to June 2016 for serum analysis of interleukin-6.Results: serum interleukin-6 was significantly [median(IQR) 14.3(26.2) pg/mL] increased in heart failure patients compared to age and sex matched controls [median(IQR) 0(2.4) pg/mL].Conclusions: Even though little is known about function of interleukin-6 in heart failure patients, this study shows that increased level of IL-6 in heart failure patients plays an important role as a pro-inflammatory marker in development of cardiovascular disease i.e. heart failure.
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Deokar et al. (2018) conducted a case-control in Heart failure (n=44). Serum interleukin-6 vs. Healthy controls was evaluated on Serum interleukin-6 level (pg/mL) (p=<0.0005). Serum interleukin-6 levels were significantly higher in heart failure patients (median 14.3 pg/mL) compared to age- and sex-matched healthy controls (median 0 pg/mL).
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