Key result
The distribution of ACE gene insertion/deletion polymorphisms did not differ significantly between COPD patients with and without bronchial hyperresponsiveness (P=0.591).
Why the study?
Does ACE gene polymorphism associate with bronchial hyperresponsiveness or disease severity in patients with COPD?
Observational (n=100)
No
Does ACE gene polymorphism associate with bronchial hyperresponsiveness or disease severity in patients with COPD?
ACE gene insertion/deletion polymorphisms do not appear to be associated with bronchial hyperresponsiveness or disease severity in patients with COPD.
No association seen in this cross-sectional COPD cohort; leaves open whether ACE polymorphisms influence phenotypes in prospective studies.
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Kim et al. (2005) conducted an observational in Chronic Obstructive Pulmonary Disease (COPD) (n=100). ACE gene insertion/deletion (I/D) polymorphism vs. Different ACE genotypes (DD, ID, II) was evaluated on Difference in ACE genotype distribution between COPD patients with and without bronchial hyperresponsiveness (p=0.591). The distribution of ACE gene insertion/deletion polymorphisms did not differ significantly between COPD patients with and without bronchial hyperresponsiveness (P=0.591).
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