Key result
ACE gene insertion/deletion polymorphism was associated with increased COPD risk in the Asian population (recessive model OR 3.326; 95% CI 2.190-5.050; P<0.001), but not in Caucasians or overall.
Why the study?
Is the insertion/deletion polymorphism of the ACE gene associated with the risk of COPD?
Meta-Analysis
Is the insertion/deletion polymorphism of the ACE gene associated with the risk of COPD?
Odds Ratio: 3.326 (95% CI 2.19–5.05)
p-value: p=<0.001
The ACE gene insertion/deletion polymorphism may increase susceptibility to COPD in Asian populations, but not in Caucasian populations.
Does not support routine ACE genotyping for COPD risk; extends conflicting evidence on ethnic-specific genetic associations.
The relationship between polymorphism of the angiotensin I converting enzyme ( ACE ) gene and chronic obstructive pulmonary disease (COPD) has been examined in many previous studies. However, their results were controversial. Therefore, we performed a meta-analysis to evaluate the relationship between the ACE gene and the risk of COPD. Fourteen case-control studies were included in this meta-analysis. The pooledpvalue, odds ratio (OR), and 95% confidence interval (95% CI) were used to investigate the strength of the association. The meta-analysis was performed using comprehensive meta-analysis software. Our meta-analysis results revealed that ACE polymorphisms were not related to the risk of COPD (p>0.05in each model). In further analyses based on ethnicity, we observed an association between insertion/deletion polymorphism of the ACE gene and risk of COPD in the Asian population (codominant 2, OR = 3.126, 95% CI = 1.919–5.093,p<0.001; recessive, OR = 3.326, 95% CI = 2.190–5.050,p<0.001) but not in the Caucasian population (p>0.05in each model). In conclusion, the present meta-analysis indicated that the insertion/deletion polymorphism of the ACE gene may be associated with susceptibility to COPD in the Asian population but not in the Caucasian population. However, the results of the present meta-analysis need to be confirmed in a larger sample.
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Kang et al. (2016) conducted a meta-analysis in Chronic obstructive pulmonary disease (COPD). ACE gene insertion/deletion polymorphism vs. Other genotypes was evaluated on Risk of COPD (Asian population, recessive model) (OR 3.326, 95% CI 2.190-5.050, p=<0.001). ACE gene insertion/deletion polymorphism was associated with increased COPD risk in the Asian population (recessive model OR 3.326; 95% CI 2.190-5.050; P<0.001), but not in Caucasians or overall.
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