Surface-patterned 2-hydroxyethyl methacrylate hydrogels were produced by using a method similar to the silicon-rubber stamp fabrication for microcontact printing. Polymerization and network formation were carried out in contact with a micromachined silicon wafer. The polymeric patterns retained their shape during isotropic swelling/deswelling cycles. The use of microstructured hydrogels in tissue engineering can be envisaged.
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Chiellini et al. (2001) studied this question.