Key result
Right minithoracotomy and lower hemisternotomy for isolated mitral valve repair demonstrated similar 15-year survival (69% vs 89%, P<0.9) and long-term durability.
Why the study?
Right minithoracotomy and lower hemisternotomy for minimally invasive mitral valve repair have improved short-term outcomes, but they have not been directly compared.
Does right minithoracotomy compared to lower hemisternotomy affect long-term survival and freedom from reoperation in patients undergoing isolated mitral valve repair?
Cohort (n=819)
Does right minithoracotomy compared to lower hemisternotomy affect long-term survival and freedom from reoperation in patients undergoing isolated mitral valve repair?
Absolute Event Rate: 69% vs 89%
p-value: p=<0.9
Right minithoracotomy and lower hemisternotomy for isolated mitral valve repair offer comparable and excellent long-term survival and freedom from reoperation at up to 15 years of follow-up.
Either approach may suit isolated mitral repair by expertise; leaves open randomized confirmation of equivalence.
Objective Minimally invasive mitral valve repair has been increasingly adopted. Right minithoracotomy (RT) and lower hemisternotomy (HS) have each been associated with improved short-term outcomes; however, these approaches have not been directly compared to each other. The aim of this study was to compare long-term survival and durability of 2 minimally invasive approaches to mitral repair. Methods We retrospectively identified all isolated mitral repairs performed via RT or HS between October 1997 and June 2018; 100 RT cases and 719 HS cases were included. Outcomes of interest were postoperative complications, long-term survival, and freedom from mitral reoperation. A Cox proportional hazard model was used to compare RT and HS to a reference cohort of full-sternotomy cases. Total observation time was 9,901 patient-years and mean follow-up time was 12.2 years. Results Mean age was 58±12 years in the RT group and 56±13 years in the HS group ( P = 0.2). The RT group had longer bypass (143 minutes vs. 112 minutes; P < 0.001) and cross-clamp times (99 minutes vs. 78 minutes; P < 0.001) compared with the HS group. There were no differences in operative mortality or 30-day outcomes. Survival at 5, 10, and 15 years was 99% (96-100), 92% (85-100), and 69% (30-100) in the RT group and 98% (97-99), 92% (90-94), and 89% (86-92) for HS ( P < 0.9). There were no differences in risk-adjusted survival between RT, HS and full sternotomy. No long-term mitral reoperations occurred in the RT group and 8 (1%) occurred in the HS group ( P < 0.50). Conclusions Minimally invasive mitral valve repair can be performed safely through RT or HS with excellent survival and durability at 15 years.
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Percy et al. (2020) conducted a cohort in Isolated mitral valve repair (n=819). Right minithoracotomy vs. Lower hemisternotomy was evaluated on 15-year survival (p=<0.9). Right minithoracotomy and lower hemisternotomy for isolated mitral valve repair demonstrated similar 15-year survival (69% vs 89%, P<0.9) and long-term durability.
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