Key result
Apolipoprotein E polymorphism was not significantly associated with essential hypertension in Korean adults, with no significant differences in genotype frequencies between hypertensive groups (p=0.498).
Why the study?
Does apolipoprotein E polymorphism affect the risk of essential hypertension in Korean adults?
Cross-Sectional (n=1,243)
Does apolipoprotein E polymorphism affect the risk of essential hypertension in Korean adults?
Apolipoprotein E polymorphism is not significantly associated with the prevalence of essential hypertension in the Korean adult population.
Does not support ApoE polymorphism for hypertension risk assessment in Korean adults; leaves open its role in other populations or designs.
Background: Apolipoprotein E has been one of the most thoroughly studied genetic polymorphisms, particularly for its effects on lipid profiles and coronary heart disease risk. This study investigated the relationship between the apolipoprotein E polymorphism and essential hypertension in a Korean population. Methods: The subjects (n=1,243) were participants in a population-based study in Incheon metropolitan City, Korea. The apolipoprotein E polymorphism was determined using a polymerase chain reaction method. Results: The frequencies of the genotypes did not differ significantly between the hypertensive groups (60.0% ε2 / ε2, 30.8% ε2 / ε3, 44.4% ε2 / ε4, 33.3% ε3 / ε3, 32.3% ε3 / ε4, and 15.4% ε4 / ε4; p=0.498). After adjusting for other risk factors, genotypes were not associated with hypertension(OR 5.74, 95% CI 0.81-40.76, ε2 / ε2 vs. ε3 / ε3; OR 0.94, 95% CI 0.60-1.47, ε2 / ε3 vs. ε3 / ε3; OR 1.21, 95% CI 0.30-4.89, ε2 / ε4 vs. ε3 / ε3; OR 0.79, 95% CI 0.56-1.13, ε3 / ε4 vs. ε3 / ε3; OR 0.29, 95% CI 0.06-1.45, ε4 / ε4 vs. ε3 / ε3). Conclusions: These findings suggest that the apolipoprotein E polymorphism is not associated with hypertension.
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Choi et al. (2007) conducted a cross-sectional in Essential hypertension (n=1,243). Apolipoprotein E (APOE) polymorphism vs. ɛ3/ɛ3 genotype was evaluated on Hypertension prevalence (OR 5.74, 95% CI 0.81-40.76, p=0.498). Apolipoprotein E polymorphism was not significantly associated with essential hypertension in Korean adults, with no significant differences in genotype frequencies between hypertensive groups (p=0.498).
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