Why the study?
Is the APOE promoter polymorphism (A -491T) associated with essential hypertension or blood pressure variation in a Japanese population?
Population
375 Japanese individuals, comprising 180 hypertensives with a family history of hypertension and 195 age…
Comparison
Presence of APOE promoter polymorphism and… vs Absence of the polymorphism / different genotypes
Design
Case-control
Authors
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APOE promoter variant was not linked to hypertension; leaves open minor role in diastolic BP variation among normotensives.
Is the APOE promoter polymorphism (A -491T) associated with essential hypertension or blood pressure variation in a Japanese population?
The APOE promoter polymorphism (A -491T) is not a major risk factor for hypertension but may have a minor effect on basal diastolic blood pressure variation in normotensive Japanese individuals.
Katsuya et al. (2000) studied this question.
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