Why the study?
Are apolipoprotein E and angiotensin-converting enzyme gene polymorphisms associated with silent myocardial ischemia in asymptomatic Japanese subjects?
Population
190 Japanese subjects selected from 3,920 asymptomatic subjects undergoing general checkups. Controls were…
Comparison
Apolipoprotein E and angiotensin-converting… vs Absence of these specific alleles
Design
Case-control
Authors
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ε4 allele may mark silent ischemia risk in asymptomatic Japanese; hypothesis-generating, needs prospective validation before practice change.
Are apolipoprotein E and angiotensin-converting enzyme gene polymorphisms associated with silent myocardial ischemia in asymptomatic Japanese subjects?
The apolipoprotein epsilon4 allele is an independent genetic risk factor for silent myocardial ischemia in asymptomatic Japanese subjects.
Nakata et al. (1996) studied this question.
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