Key result
Carrying the T-allele of the GNB3 825C/T polymorphism was not significantly associated with essential hypertension (OR 1.23; 95% CI 0.94-1.62; P=0.13) or myocardial infarction.
Why the study?
Is the 825C/T polymorphism of the GNB3 gene associated with an increased risk of essential hypertension or myocardial infarction?
Population
2,186 subjects from two case-control studies: PEGASE and ECTIM
Comparison
Presence of the 825T allele vs Absence of the 825T allele
Design
Case-control
Authors
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Does not support GNB3 825C/T as hypertension or MI risk factor; challenges prior reports but leaves association open for larger studies.
Case-Control (n=2,186)
Yes
Is the 825C/T polymorphism of the GNB3 gene associated with an increased risk of essential hypertension or myocardial infarction?
Odds Ratio: 1.23 (95% CI 0.94–1.62)
p-value: p=0.13
The 825C/T polymorphism of the GNB3 gene does not appear to be a significant risk factor for essential hypertension or myocardial infarction, challenging previous reports.
Brand et al. (1999) conducted a case-control in Hypertension and Myocardial Infarction (n=2,186). 825C/T polymorphism of the GNB3 gene (T-allele carrying) vs. Non-carriers was evaluated on Essential hypertension (OR 1.23, 95% CI 0.94-1.62, p=0.13). Carrying the T-allele of the GNB3 825C/T polymorphism was not significantly associated with essential hypertension (OR 1.23; 95% CI 0.94-1.62; P=0.13) or myocardial infarction.
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