Influence of methyl substituents on the chemical shift of the ring protons in mono‐, di‐ and trimethylcyclohexanes a 300 MHz study of the 1H NMR spectrum of cis‐1,3‐dimethylcyclohexane

From a 300 MHz spectral study of mono‐to trisubstituted cyclohexanes, allowing a re‐examination of some of their 1H NMR spectral parameters, it is shown that it is possible to predict with reasonable accuracy the shifts (in CCl4) of the ring protons. A substantial feature in this is the validity of the (questioned) additivity of multiple effects. It is also shown that with respect to shift alterations, equatorial ring protons behave anomalously, which cannot be explained by any existing theoretical model.