Key result
In patients with cerebral small vessel disease, mild cognitive impairment was associated with higher mean diffusion (P=0.022) and lower fractional anisotropy (P=0.047) in the right anterior cingulate gyrus.
Why the study?
The study was conducted to distinguish microstructural changes in the cingulate cortex in patients with mild cognitive impairment induced by cerebral small vessel disease.
Does diffusion kurtosis imaging detect microstructural changes in the cingulate cortex of patients with mild cognitive impairment induced by cerebral small vessel disease?
Cross-Sectional (n=80)
Does diffusion kurtosis imaging detect microstructural changes in the cingulate cortex of patients with mild cognitive impairment induced by cerebral small vessel disease?
p-value: p=0.022
Diffusion kurtosis imaging can detect early microstructural damage in the cingulate cortex of patients with mild cognitive impairment induced by cerebral small vessel disease.
Cingulate microstructure changes may aid MCI detection in CSVD; leaves open whether DKI metrics predict outcomes or alter management.
Objective: The purpose of our study was to distinguish the changes in the microstructure of the cingulate cortex in patients with mild cognitive impairment (MCI) induced by cerebral small vessel disease (CSVD).Method: 80 patients were diagnosed with CSVD in this study, including 55 patients with MCI and 25 patients without MCI. Diffusion kurtosis imaging (DKI) and Montreal cognitive assessment (MoCA) were performed in all patients. The anterior cingulate gyrus, posterior cingulate gyrus and middle cingulate gyrus were selected as the regions of interest, and some parameters were recorded.Results: Compared with the non-MCI group, the MCI group mainly showed obviously higher mean diffusion (MD) and radial diffusion (RD) values (P = 0.022 and P = 0.029) but lower fractional anisotropy (FA), axial kurtosis (AK), mean kurtosis (MK) and radial kurtosis (RK) values (P = 0.047, P = 0.001, P < 0.01, and P = 0.001, respectively) in the right anterior cingulate gyrus. Meanwhile, in the right posterior cingulate gyrus, the MCI group also showed higher axial diffusion (AD) and MD (P = 0.027 and P = 0.030) and lower AK (P = 0.014). Additionally, negative correlations of AD, MD, and RD with MoCA scores and positive correlations of FA, AK, MK and RK with MoCA scores were observed in some regions of the cingulate gyrus.Conclusions: DKI is a good method to examine microstructural damage in the cingulate cortex, and some parameters of DKI may be used as imaging biomarkers to detect early MCI in patients with CSVD.
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Liu et al. (2021) conducted a cross-sectional in Cerebral small vessel disease (n=80). Mild cognitive impairment vs. Patients without mild cognitive impairment was evaluated on Microstructural changes in the cingulate cortex measured by diffusion kurtosis imaging (p=0.022). In patients with cerebral small vessel disease, mild cognitive impairment was associated with higher mean diffusion (P=0.022) and lower fractional anisotropy (P=0.047) in the right anterior cingulate gyrus.
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