Key result
Blood flow-induced shear stress on arterial endothelial cells modulates underlying smooth muscle tone, continuously adapting arterial hydraulic resistance to blood flow rate and viscosity.
Describes the physiological mechanism by which endothelial cells use shear stress to regulate arterial tone and hydraulic resistance.
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Does not alter clinical practice; leaves open translation of endothelial shear mechanisms to vascular disease therapies.
Melkumyants et al. (1995) studied this question. Blood flow-induced shear stress on arterial endothelial cells modulates underlying smooth muscle tone, continuously adapting arterial hydraulic resistance to blood flow rate and viscosity.
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