What question did this study set out to answer?

The aim is to explore how endothelial cells sense shear stress and its implications for vascular physiology and pathology.

Sensing of shear stress in vascular endothelial cells – from physiology to pathology

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This review discusses shear stress sensing in endothelial cells, highlighting its impact on vascular health and disease.

The aim is to explore how endothelial cells sense shear stress and its implications for vascular physiology and pathology.
Reviewed existing literature on endothelial shear stress sensing mechanisms.
Examined the role of mechanosensitive proteins and structures in endothelial cells.
Highlighted unanswered questions in current vascular biology research.
Endothelial cells use various proteins to convert shear stress into biochemical signals.
Disruption in shear stress sensing is linked to diseases like atherosclerosis.
Understanding these mechanisms can inform future research and therapies for vascular diseases.

Chuntharpursat‐Bon et al. (2026) studied this question.

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