Key result
Augmented exercise-induced shear stress contributes to improved endothelial function, whereas retrograde shear initiates vascular dysfunction.
This review highlights the mechanisms by which exercise-induced shear stress improves endothelial function and how retrograde shear contributes to vascular dysfunction.
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May guide shear-optimized exercise trials; leaves open whether modulating retrograde shear alters clinical vascular outcomes.
Johnson et al. (2011) conducted a review in Atherosclerosis and endothelial dysfunction. Shear stress was evaluated. Augmented exercise-induced shear stress contributes to improved endothelial function, whereas retrograde shear initiates vascular dysfunction.
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