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The glucose metabolism in intact lymphocyte cells was found to be altered in the presence of phytohemagglutinin. The operation of the pentose phosphate pathway and, to some extent, the pentose cycle pathway in lymphocytes was found to be significantly enhanced. This finding is interpreted to reflect an additional need of biosynthetic intermediates and TPNH by the lymphocytes to accommodate mitotic activity induced by phytohemagglutinin.
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MACHAFFIE et al. (1967) studied this question.
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