Key result
In patients with advanced renal failure, functional diastolic murmurs mimicking aortic insufficiency were observed to disappear during treatment with hemodialysis and renal transplantation.
Why the study?
Does hemodialysis and renal transplantation resolve functional diastolic murmurs in patients with advanced renal failure?
Observational (n=21)
Does hemodialysis and renal transplantation resolve functional diastolic murmurs in patients with advanced renal failure?
Diastolic decrescendo murmurs in advanced renal failure are often functional and resolve with hemodialysis or renal transplantation.
May support resolution of functional murmurs with renal replacement; hypothesis-generating case report needing prospective validation.
A diastolic decrescendo murmur was heard along the left sternal border in 21 patients with advanced renal failure. Eight patients had organic aortic insufficiency. Among the remaining 13 patients, angiocardiography was carried out in 6; aortic regurgitation was demonstrated in 4, while 2 had stenosis of a coronary artery. Two of the 5 patients with positive angiography have died. At autopsy the aortic ostium was normal. The diastolic murmur in these patients is thought to be functional. It disappears during treatment with hemodialysis and renal transplantation.
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Storstein et al. (1978) conducted an observational in Advanced renal failure (n=21). Hemodialysis and renal transplantation was evaluated on Cause and resolution of diastolic decrescendo murmur. In patients with advanced renal failure, functional diastolic murmurs mimicking aortic insufficiency were observed to disappear during treatment with hemodialysis and renal transplantation.