Key result
Endotoxin induced a dramatic fall in recoverable macrophages, an influx of neutrophils, and anti-fibrinolytic activity in endotoxin-sensitive C3H/HeN mice, but not in resistant C3H/HeJ mice.
Stimulated macrophages can initiate pro-coagulant, fibrinolytic, and anti-fibrinolytic pathways coordinately regulated by environmental signals like endotoxin.
No takes yet. Share an insight, caveat, or question.
Macrophage-endotoxin interactions may modulate fibrinolysis in inflammation; leaves open translation to human sepsis coagulopathy.
Chapman et al. (1983) studied Inflammatory processes. Endotoxin vs. Endotoxin-unresponsive C3H/HeJ mice was evaluated on Macrophage procoagulant and fibrinolytic activity. Endotoxin induced a dramatic fall in recoverable macrophages, an influx of neutrophils, and anti-fibrinolytic activity in endotoxin-sensitive C3H/HeN mice, but not in resistant C3H/HeJ mice.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: