Key result
Cornus officinalis and its active compounds demonstrate therapeutic potential for diabetic nephropathy by regulating glucose and lipid metabolism, reducing oxidative stress, and protecting podocytes.
Why the study?
Diabetic nephropathy has become the leading cause of chronic kidney disease in China, but no definitive cure currently exists.
This review highlights the multi-targeted mechanisms of Cornus officinalis in treating diabetic nephropathy, providing a basis for future research on its active components.
Hypothesis-generating for Cornus officinalis in diabetic nephropathy; randomized trials needed before any clinical consideration.
Diabetic nephropathy (DN) is a kidney disorder secondary to diabetes and is one of the main diabetic microvascular complications. As the number of diabetic patients grows, DN has become the leading cause of chronic kidney disease in China. Unfortunately, no definitive cure currently exists for DN. Cornus officinalis (CO), frequently utilized in clinical settings for diabetes mellitus treatment, has proven vital in both preventing and treating DN. This article explores the pathogenesis of DN and how CO and its active compounds regulate glucose and lipid metabolism, exhibit anti-inflammatory properties, inhibit oxidative stress, regulate podocytes, and manage autophagy. The mechanism and role of and its active compounds in the treatment of DN are discussed.
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Wu et al. (2023) conducted a review in Diabetic nephropathy. Cornus officinalis and its active compounds was evaluated. Cornus officinalis and its active compounds demonstrate therapeutic potential for diabetic nephropathy by regulating glucose and lipid metabolism, reducing oxidative stress, and protecting podocytes.
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