A new biodegradable poly(l-aspartic acid-co-poly(ethylene glycol)) having pendant amine functional groups was synthesized by the melt polycondensation reaction of prepolymer prepared from N-(benzyloxycarbonyl)-l-aspartic acid anhydride (N-Z-l-aspartic acid anhydride) and poly(ethylene glycol). The synthesized polymer was characterized by FTi.r., 1H n.m.r., d.s.c., g.p.c. and solubility. The weight-average molecular weight of the prepolymer increased about 11 times via melt polycondensation at 160°C in a vacuum for <1 h.
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Won et al. (1998) studied this question.