Gastric secretion was stimulated by sham feeding in Pavlov pouch dogs with esophageal fistulae and isolated pouches of the duodenal bulb. Reduction of the intrabulbar pH to pH 3–4 inhibited the acid response to sham feeding. Bulbar acidification was more effective in inhibiting acid responses to 1 and 10 min of sham feeding than responses to 30 min of sham feeding. Short periods of bulbar acidification were sufficient to activate the bulbar inhibitory mechanism.
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Göran Nilsson (1969) studied this question.
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