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The regional distribution of peptidergic nerves in the juvenile and adult human prostate has been studied immunohistochemically using highly specific polyclonal antibodies. Nerves displaying immunoreactivity of Met-enkephalin, Leu-enkephalin, heptapeptide and octapeptide were detected in the dorsolateral stroma closely related to smooth muscle predominantly of juvenile glands. A less strong immunoreactivity was present around stromal vessels and periurethral. Subepithelial peri-acinar nerves showing Leu-enkephalin, Met-enkephalin, octa- and heptapeptide immunoreactivity were found in a few instances. The most prominent immunoreaction was achieved with octapeptide antiserum, followed in decreasing order by Met-enkephalin, Leu-enkephalin and heptapeptide. Their density decreased with age. Antisera against beta-endorphin, alpha-neoendorphin, beta-neoendorphin and dynorphin A gave to positive immunoreaction with prostatic nerves. The regional distribution pattern described is in favor of a postsynaptic peptidergic sympathetic innervation of prostatic stroma acting with classical neurotransmitters.
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Jungblut et al. (2010) studied this question.
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