Key result
Ankylosing spondylitis was associated with significantly impaired flow-mediated vasodilation (6.85% vs 8.30%), increased carotid intima-media thickness, and higher pulse-wave velocity.
Why the study?
Does ankylosing spondylitis increase subclinical vascular disease (impaired FMD, increased ccIMT, and higher PWV) compared to healthy controls?
Population
43 patients with ankylosing spondylitis and 40 age- and sex-matched healthy controls. Exclusions: history of…
Comparison
Ankylosing spondylitis vs Healthy controls matched for age and sex
Design
Cross-sectional
Authors
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May signal heightened CV risk in ankylosing spondylitis; cross-sectional data leave causality and screening implications open.
Case-Control (n=83)
No
Does ankylosing spondylitis increase subclinical vascular disease (impaired FMD, increased ccIMT, and higher PWV) compared to healthy controls?
Absolute Event Rate: 6.85% vs 8.3%
p-value: p=0.005
Patients with ankylosing spondylitis exhibit significant subclinical vascular disease, including endothelial dysfunction, increased carotid atherosclerosis, and aortic stiffness, which correlate with disease duration and functional impairment.
Bodnár et al. (2011) conducted a case-control in Ankylosing Spondylitis (n=83). Ankylosing Spondylitis vs. Healthy controls was evaluated on Flow-mediated vasodilation (FMD) (p=0.005). Ankylosing spondylitis was associated with significantly impaired flow-mediated vasodilation (6.85% vs 8.30%), increased carotid intima-media thickness, and higher pulse-wave velocity.
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