Key result
Structural alterations in myelin basic protein, specifically the less cationic rmC8 isoform, expose immunodominant epitopes to proteases, potentially initiating or contributing to demyelination in MS.
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Cynthia Husted (2006) conducted an editorial in Multiple sclerosis. Myelin basic protein (MBP) structural alterations was evaluated. Structural alterations in myelin basic protein, specifically the less cationic rmC8 isoform, expose immunodominant epitopes to proteases, potentially initiating or contributing to demyelination in MS.
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