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November 1, 2025The Journal of ImmunologyOpen Access

Antibodies against Myelin Proteolipid Protein (PLP) drive inflammation and demyelination in multiple sclerosis 4560

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Authors

TLTobias V Lanz

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Overview

Study reveals anti-PLP antibodies drive inflammation and demyelination in multiple sclerosis, indicating a potential target for therapy.

Key Points

  • The research aims to characterize the pathogenic role of anti-PLP B cell responses in multiple sclerosis.
  • Sequenced the single-cell B cell repertoire in the cerebro-spinal fluid of MS patients.
  • Tested individual B cell receptors for reactivity to protein Myelin Proteolipid Protein.
  • Identified BCRs that bind with high affinity to PLP.
  • Studied the effects of anti-PLP antibodies on primary rat oligodendrocytes.
  • Anti-PLP antibodies induce apoptosis in oligodendrocytes independent of CDC and ADCC.
  • Patient-derived anti-PLP antibodies exacerbated MS models by attracting immune cells to the CNS.
  • Unmutated germline sequences showed no reactivity to PLP.

Cite This Study

Tobias V Lanz (2025) studied this question.

synapsesocial.com/papers/69254f8ec0ce034ddc3598c7https://doi.org/10.1093/jimmun/vkaf283.2229
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Combinatorial antibody library from multiple sclerosis patients reveals antibodies that cross‐react with myelin basic protein and EBV antigen2011 · 85 citations
  2. 2Cells of Cerebrospinal Fluid of Multiple Sclerosis Patients Secrete Antibodies to Myelin Basic Protein In Vitro1992 · 9 citations
  3. 3CSF1R inhibition following antibody mediated demyelination has limited impact on remyelination2026
  4. 4Maintenance of chronic neuroinflammation in multiple sclerosis via interferon signaling and CD8 T-cell-mediated cytotoxicity2025
  5. 5Modulation of the immune response in multiple sclerosis: production of monoclonal antibodies specific to HLA/myelin basic protein1997 · 16 citations