Why the study?
Do monoclonal antibodies specific to HLA/MBP complexes block the in vitro proliferative response of MBP-specific T cell clones from multiple sclerosis patients?
Population
Human antigen-presenting cells and myelin basic protein-specific T cell clones isolated from multiple…
Comparison
Monoclonal antibodies specific to the complex… vs APCs of different DR restriction or pulsed with…
Design
Preclinical
Authors
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May enable selective autoreactive T-cell blockade in MS; leaves open in vivo efficacy and clinical translation.
Do monoclonal antibodies specific to HLA/MBP complexes block the in vitro proliferative response of MBP-specific T cell clones from multiple sclerosis patients?
Monoclonal antibodies targeting specific HLA/MBP complexes can selectively block autoreactive T cell proliferation in vitro, suggesting a potential targeted therapeutic approach for multiple sclerosis.
Puri et al. (1997) studied this question.
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