What does this research mean for the field?

The human T cell response to myelin basic protein in multiple sclerosis is highly heterogeneous in epitope specificity and T cell receptor usage, though a subset of patients exhibits a stable, restricted response to patient-specific immunodominant epitope clusters driven by multiple T cell clones. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 1, 1993Journal of Clinical InvestigationOpen Access

Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones.

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Implication

Heterogeneity of MBP-specific T cells may limit single-peptide therapies in MS; leaves open identification of dominant or shared targets.

Cite This Study

Meinl et al. (1993) studied this question.

synapsesocial.com/papers/6a1b252a51cb8e0412c3fac3 https://doi.org/10.1172/jci116879

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Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones.

Key Points

Discussion

Implication

Cite This Study

Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones.

Key Points

Discussion

Implication

Cite This Study

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