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August 22, 2011The FASEB Journal

Combinatorial antibody library from multiple sclerosis patients reveals antibodies that cross‐react with myelin basic protein and EBV antigen

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Key result

Antibodies from multiple sclerosis patients cross-reacted with both myelin basic protein and Epstein-Barr virus latent membrane protein 1, suggesting molecular mimicry in MS pathogenesis.

Population

Blood lymphocytes from patients with multiple sclerosis (MS)

Design

Preclinical

Authors

AGAlexander G. GabibovABAlexey A. BelogurovYLYakov A. Lomakin

Discussion

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Overview

May implicate EBV in MS autoimmunity; animal data leave open human therapeutic relevance.

Structured PICO

P
Population
Patients with multiple sclerosis whose blood lymphocytes were used to construct a phage display library to analyze autoantibody cross-reactivity.
E
Exposure
Construction of a phage display library of single-chain variable fragments (scFvs) and selection toward myelin basic protein (MBP)
O
Outcome
Cross-reactivity of selected scFv clones with MBP and Epstein-Barr latent membrane protein 1 (LMP1)surrogate

Antibodies induced against EBV LMP1 may cross-react with myelin basic protein, suggesting molecular mimicry as a potential mechanism for MS pathogenesis.

Cite This Study

Gabibov et al. (2011) studied Multiple sclerosis. Antibodies from MS patients was evaluated on Cross-reactivity of scFv clones with myelin basic protein and Epstein-Barr latent membrane protein 1. Antibodies from multiple sclerosis patients cross-reacted with both myelin basic protein and Epstein-Barr virus latent membrane protein 1, suggesting molecular mimicry in MS pathogenesis.

synapsesocial.com/papers/6a93021c7dc82e97087f517fhttps://doi.org/10.1096/fj.11-190769
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Autoantibodies to myelin basic protein catalyze site-specific degradation of their antigen2005 · 182 citations
  2. 2Identification and prevalence of CD8<sup>+</sup> T‐cell responses directed against Epstein‐Barr virus‐encoded latent membrane protein 1 and latent membrane protein 22002 · 103 citations
  3. 3Modulation of Epstein-Barr Virus Latent Membrane Protein 1 Activity by Intrabodies2007 · 7 citations
  4. 4Antibody responses to Epstein‐Barr virus‐encoded latent membrane protein‐1 (LMP1) and expression of LMP1 in juvenile Hodgkin's disease2002 · 30 citations
  5. 5Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain2007 · 769 citations