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July 11, 2026Acta Neuropathologica CommunicationsOpen Access

CSF1R inhibition following antibody mediated demyelination has limited impact on remyelination

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Authors

LGLisa C. GoldenGPGraham C. PeetRRRebecca E. Rodriguez

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Overview

Randomized trial investigates effects of CSF1R inhibition on remyelination in mice, indicating limited efficacy.

Key Points

  • To explore how CSF1R inhibition affects remyelination following antibody-mediated demyelination in a mouse model of MS.
  • Used PLP1c recombinant antibody in mice to induce demyelination, monitored lesion development over four weeks.
  • Applied CSF1R inhibition to target microglia depletion during recovery from demyelination.
  • Total microglia were significantly reduced after CSF1R inhibition, yet macrophage density remained high in recovering lesions.
  • Alterations were seen in premyelinating oligodendrocyte populations without affecting overall lesion recovery.

Cite This Study

Golden et al. (2026) studied this question.

synapsesocial.com/papers/6a51deadc18d7f28ca50047dhttps://doi.org/10.1186/s40478-026-02370-3
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