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October 1, 1994Journal of NeuroscienceOpen Access

Monoclonal autoantibodies promote central nervous system repair in an animal model of multiple sclerosis

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Key result

Monoclonal IgM autoantibodies SCH94.03 and SCH94.32 promoted fourfold more CNS remyelination than controls in a mouse model of multiple sclerosis.

Why the study?

Do monoclonal autoantibodies promote CNS remyelination in an animal model of multiple sclerosis?

Population

SJL/J mice chronically infected with Theiler's murine encephalomyelitis virus

Comparison

Monoclonal IgM autoantibodies derived from… vs Controls

Design

Preclinical

Authors

DMD J MillerMayo ClinicKSKS SanbornMayo ClinicJKJA KatzmannUniversity of Vermont

Discussion

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Implication

Supports remyelination by spinal cord-derived Ig in TMEV model; hypothesis-generating for MS, human trials required.

Structured PICO

Do monoclonal autoantibodies promote CNS remyelination in an animal model of multiple sclerosis?

P
Population
SJL/J mice chronically infected with Theiler's murine encephalomyelitis virus, serving as an animal model for multiple sclerosis.
I
Intervention
Monoclonal IgM autoantibodies (clones SCH94.03 and SCH94.32) derived from splenocytes of SJL/J mice injected with homogenized spinal cord
C
Comparator
Controls
O
Outcome
CNS remyelination (assessed morphologically by the presence of abnormally thin myelin sheaths relative to axonal diameter)surrogate

Main Result

Effect estimate: fourfold increase

Monoclonal autoantibodies can promote CNS remyelination and halt clinical disease progression in a viral murine model of multiple sclerosis.

Cite This Study

Miller et al. (1994) studied Multiple sclerosis (animal model). Monoclonal IgM autoantibodies (SCH94.03 and SCH94.32) vs. controls was evaluated on CNS remyelination (fourfold increase). Monoclonal IgM autoantibodies SCH94.03 and SCH94.32 promoted fourfold more CNS remyelination than controls in a mouse model of multiple sclerosis.

synapsesocial.com/papers/6a6f17a26c240de38cdb6261https://doi.org/10.1523/jneurosci.14-10-06230.1994
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanisms of Virus‐Induced Demyelination and Remyelinationa1988 · 6 citations
  2. 2Remyelination by Oligodendrocytes Stimulated by Antiserum to Spinal Cord1987 · 105 citations
  3. 3Double-Blind Pilot Trial of Oral Tolerization with Myelin Antigens in Multiple Sclerosis1993 · 590 citations
  4. 4Experimental models of virus‐induced demyelination of the central nervous system1982 · 174 citations
  5. 5Immunological Aspects of Demyelinating Diseases1992 · 1,015 citations