Key result
Polyclonal human IgG (IVIG) and polyclonal human IgM promoted remyelination in mice with virus-induced demyelinating disease, with IgM being more potent.
Why the study?
Do polyclonal human IgG and IgM promote remyelination in a mouse model of virus-induced demyelinating disease?
Population
Mice with chronic Theiler's murine encephalomyelitis virus-induced demyelinating disease
Design
Preclinical
Authors
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May inform ongoing IVIG trials in MS; leaves open clinical translation from mouse remyelination data.
Do polyclonal human IgG and IgM promote remyelination in a mouse model of virus-induced demyelinating disease?
Polyclonal human IgM and IgG promote remyelination in a viral model of demyelination, suggesting potential synergistic therapeutic strategies for multiple sclerosis.
Bieber et al. (2000) studied Theiler's murine encephalomyelitis virus-induced demyelinating disease. Polyclonal human IgG (IVIG) and polyclonal human IgM was evaluated on Remyelination. Polyclonal human IgG (IVIG) and polyclonal human IgM promoted remyelination in mice with virus-induced demyelinating disease, with IgM being more potent.
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