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June 1, 1983HeartOpen Access

Echocardiographic features of free floating thrombus mimicking right ventricular myxoma.

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Population

Experimental autoimmune encephalomyelitis (EAE) animal model of multiple sclerosis (MS)

Comparison

Anti-CSF-1 neutralizing monoclonal antibody vs CSF-1R inhibitor BLZ945 or IL-34 neutralization

Design

Preclinical

Authors

MSM F ShiuLAL D Abrams

Discussion

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Overview

Supports CSF-1 neutralization in EAE; hypothesis-generating for MS translation.

Structured PICO

P
Population
Experimental autoimmune encephalomyelitis (EAE) animal model of multiple sclerosis (MS)
I
Intervention
Anti-CSF-1 neutralizing monoclonal antibody
C
Comparator
CSF-1R inhibitor BLZ945 or IL-34 neutralization
O
Outcome
Ongoing EAE pathology and myeloid cell populations in the CNSsurrogate

Targeting CSF-1 with neutralizing antibodies halts EAE progression by selectively depleting inflammatory myeloid cells, offering a potential targeted therapy for multiple sclerosis.

Cite This Study

Shiu et al. (1983) studied this question.

synapsesocial.com/papers/6a9540f6bfa5337e2a0f33fahttps://doi.org/10.1136/hrt.49.6.612
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CSF1R antagonism results in increased supraspinal infiltration in EAE2024 · 3 citations
  2. 2CSF1R inhibition following antibody mediated demyelination has limited impact on remyelination2026
  3. 3Targeting CNS myeloid infiltrates provides neuroprotection in a progressive multiple sclerosis model2024 · 11 citations
  4. 4Reduced colony‐stimulating factor 1 receptor expression in myeloid cells has limited impact on chronic lymphocytic leukaemia progression2026
  5. 5Reduced CSF1R expression in myeloid cells has limited impact on chronic lymphocytic leukemia progression2025