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July 28, 2026British Journal of HaematologyOpen Access

Reduced colony‐stimulating factor 1 receptor expression in myeloid cells has limited impact on chronic lymphocytic leukaemia progression

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Authors

NRNatascha RosenGRGuillermo Rodríguez‐RealASAlexander F. vom Stein

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Overview

Randomized trial examines CSF1R's role in CLL progression, suggesting limited therapeutic effects.

Key Points

  • This research aims to understand the role of CSF1R expression in the progression of chronic lymphocytic leukaemia (CLL) and its microenvironment.
  • Created Eμ-TCL1 transgenic mice with Csf1r haploinsufficiency to study myeloid cell changes and leukaemia progression.
  • Measured Csf1r expression levels in circulating monocytes and tissue macrophages.
  • Conducted in vitro co-culture to explore the impact of CSF1R depletion on patient-derived CLL cells.
  • Reduced Csf1r levels in mice led to decreased leukaemia at early stages but had no significant long-term effects on overall survival compared to controls.
  • Csf1r reduction did not significantly change the number of circulating monocytes or macrophages in tissues.
  • In vitro studies indicated that CSF1R depletion did not affect the survival or migration of CLL cells.

Cite This Study

Rosen et al. (2026) studied this question.

synapsesocial.com/papers/6a685d012845b684d16f07f8https://doi.org/10.1111/bjh.70700
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