Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 1, 2025CellsOpen Access

Genomic Analysis Defines Increased Circulating, Leukemia-Induced Macrophages That Promote Immune Suppression in Mouse Models of FGFR1-Driven Leukemogenesis

View Full Paper
Ask AI
Bookmark
Share

Authors

TZTing ZhangAMAtsuko MatsunagaXLXiaocui Lu

Discussion

Loading...

Member takes

Overview

Analysis identifies immune suppressive macrophages in leukemia models, suggesting targeting may enhance survival.

Key Points

  • Circulating macrophages promote immune suppression in FGFR1-driven leukemia models, leading to poor outcomes.
  • Increased levels of macrophages from myeloid derived suppressor cells are observed in leukemic mouse models.
  • scRNA-Seq reveals continuous transcriptional reprogramming of these macrophages during leukemia progression.
  • Targeting these leukemia-induced macrophages improves immune surveillance and enhances survival in mice.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68dd9537fe798ba2fc4996adhttps://doi.org/10.3390/cells14191533
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reduced CSF1R expression in myeloid cells has limited impact on chronic lymphocytic leukemia progression2025
  2. 2Reduced colony‐stimulating factor 1 receptor expression in myeloid cells has limited impact on chronic lymphocytic leukaemia progression2026
  3. 3Single-cell analysis defines highly specific leukemia-induced neutrophils and links MMP8 expression to recruitment of tumor associated neutrophils during FGFR1 driven leukemogenesis2024 · 21 citations
  4. 4Abstract 187: Macrophage instead of leukemia cell expressed PD-L1 drives T cell exhaustion and immune evasion of BCRABL1 chronic myeloid leukemia2024
  5. 5Advancing our understanding of the influence of myeloid-derived suppressor cells in chronic myeloid leukemia2025