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December 8, 2025BloodOpen Access

Dynamic crosstalk between CLL cells and lymph node fibroblasts promotes a pro-tumor microenvironment

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Authors

AFAntonio FerreiraMCMartina CardilloNCNicholas Chiorazzi

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Overview

Randomised trial reveals lymphotoxin interaction alters fibroblasts in chronic lymphocytic leukemia microenvironment, suggesting new therapeutic targets.

Key Points

  • Investigate the dynamic crosstalk between CLL cells and lymph node fibroblasts and its role in tumor microenvironment.
  • Utilized scRNA-seq to identify cellular interactions in lymph nodes from CLL patients.
  • Employed 2H2O labeling to study cell division in CLL cells.
  • Conducted co-culture experiments using human lymph node fibroblasts with CLL B-cell fractions.
  • Assessed the effects of lymphotoxin on fibroblasts in both 2-D and 3-D environments.
  • Disrupted fibroblastic reticular cell network observed in CLL patient lymph nodes.
  • Cycling CLL cells secrete lymphotoxin that activates FRCs, enhancing chemokine production.
  • Lymphotoxin treatment promoted CAF-like changes in fibroblasts, including increased PDPN expression and altered morphology.

Cite This Study

Ferreira et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dc6fhttps://doi.org/10.1182/blood-2025-241
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