Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 27, 2025Open Access

Maintenance of chronic neuroinflammation in multiple sclerosis via interferon signaling and CD8 T-cell-mediated cytotoxicity

View Full Paper
Ask AI
Bookmark
Share

Authors

DRDaniel S. ReichSRSyed Ali RazaYEYoshimi Enose‐Akahata

Discussion

Loading...

Member takes

Overview

Analysis reveals chronic neuroinflammation in multiple sclerosis linked to interferon signaling and CD8 T-cell cytotoxicity.

Key Points

  • Chronic neuroinflammation persists despite B-cell depletion, driven by CD8 T-cell cytotoxicity.
  • Proteomic networks showed PRL-associated signatures, suggesting potential biomarkers for disease.

Cite This Study

Reich et al. (2025) studied this question.

synapsesocial.com/papers/68d7b3edeebfec0fc52370a4https://doi.org/10.21203/rs.3.rs-7633686/v1
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CD4+ Trm sustain the chronic phase of auto-immune neuroinflammatory disease2024 · 1 citations
  2. 2Identification of cellular factors associated with inflammation and neurodegeneration in multiple sclerosis2025 · 2 citations
  3. 3Antibodies against Myelin Proteolipid Protein (PLP) drive inflammation and demyelination in multiple sclerosis 45602025
  4. 4Integrated multiomics profiling reveals MS-specific molecular signatures linked to progression and response to nasal anti-CD3 (Foralumab) therapy 22675242026
  5. 5Proteomics analysis of periplaque and chronic inactive multiple sclerosis lesions2024 · 2 citations