What is the clinical evidence from this study?

Study design: Observational. Population: Mechanical heart valve prosthesis dysfunction (n=48). Intervention: Surgical management (reoperation). Primary outcome: Early mortality.

December 1, 2015Open Access

Dysfunction of mechanical heart valve prosthesis: experience with surgical management in 48 patients.

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Key result

Surgical management of mechanical valve dysfunction resulted in an early mortality rate of 14.6%, with significantly higher mortality observed in emergency compared to elective reoperations (28.6% vs 3.7%, p=0.03).

Population

48 patients with mechanical valve dysfunction surgically treated between October 1996 and June 2011, mean…

Design

Cohort

Follow-up

Early outcomes (in-hospital/perioperative)

Authors

WMWei‐Guo MaYale New Haven Hospital BHBin HouShijiazhuang Yiling Pharmaceutical (China)AAAdiljan AbdurusulChinese Academy of Medical Sciences & Peking Union Medical College

Discussion

Member takes

Implication

Describes surgical approaches and early outcomes for mechanical valve dysfunction; leaves open optimal strategies pending larger prospective studies.

Study Design

Type

Observational (n=48)

Multicenter

Structured PICO

Population

48 patients (mean age 43.7 years, 70.8% female) with mechanical heart valve prosthesis dysfunction who underwent surgical management at a single center between 1996 and 2011.

Intervention

Surgical management (reoperation) including mechanical valve replacement (77.1%), bioprosthetic valve replacement (14.9%), disc rotation (4.2%), and excision of excessive knot end (2.1%).

Outcome

Early mortality and morbidityhard clinical

Surgical management of mechanical valve dysfunction is associated with significant mortality, especially in emergency cases, emphasizing the importance of adequate anticoagulation and prompt reoperation.

Limitations

Retrospective design
Relatively small number of patients
Lack of late follow-up after the reoperation
Missing information about surgical techniques and valve prostheses used in the initial valve replacement
Missing details of anticoagulation management after the initial procedure (e.g., target INR, frequency of measurements, INR values prior to dysfunction)
Information was not available about the surgical techniques and valve prostheses used in initial valve replacement
Details of anticoagulation management after the initial procedure were missing

Cite This Study

Ma et al. (2015) conducted an observational in Mechanical heart valve prosthesis dysfunction (n=48). Surgical management (reoperation) was evaluated on Early mortality. Surgical management of mechanical valve dysfunction resulted in an early mortality rate of 14.6%, with significantly higher mortality observed in emergency compared to elective reoperations (28.6% vs 3.7%, p=0.03).

synapsesocial.com/papers/6a9eb3404f443e6a88b2869e https://doi.org/10.3978/j.issn.2072-1439.2015.12.25

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Implication

Describes surgical approaches and early outcomes for mechanical valve dysfunction; leaves open optimal strategies pending larger prospective studies.

Dysfunction of mechanical heart valve prosthesis: experience with surgical management in 48 patients.

Discussion

Member takes

Implication

Study Design

Structured PICO

Limitations

Cite This Study

Dysfunction of mechanical heart valve prosthesis: experience with surgical management in 48 patients.

Discussion

Member takes

Implication

Study Design

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider